Michael J Blackman Selected Research

statine

6/2005	Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
6/2004	Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.

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Michael J Blackman Research Topics

Disease

59	Malaria 10/2023 - 08/2002
9	Rupture 01/2023 - 03/2011
5	Infections 01/2021 - 03/2004
3	Disease Progression 01/2021 - 05/2014
1	Cysts 01/2010
1	Persistent Infection 01/2010

Drug/Important Bio-Agent (IBA)

19	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 08/2002
13	Serine Proteases (Serine Protease)IBA 10/2022 - 08/2002
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2009
7	Antimalarials (Antimalarial Agents)IBA 10/2023 - 12/2009
7	SubtilisinIBA 10/2022 - 07/2004
6	AntibodiesIBA 01/2021 - 08/2002
5	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022 - 06/2003
5	plasmepsin (plasmepsin I)IBA 02/2019 - 01/2004
5	Merozoite Surface Protein 1 (MSA1)IBA 10/2015 - 11/2003
4	EnzymesIBA 01/2023 - 08/2002
4	AntigensIBA 01/2021 - 08/2002
3	Phospholipases (Phospholipase)IBA 10/2023 - 01/2023
3	Hemoglobins (Hemoglobin)IBA 01/2023 - 01/2004
3	Phospholipids (Phosphatides)FDA LinkGeneric 12/2022 - 11/2013
3	VaccinesIBA 01/2021 - 08/2002
3	CalciumIBA 01/2021 - 08/2002
3	SpectrinIBA 01/2021 - 10/2015
3	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2021 - 05/2013
3	Cysteine Proteases (Cysteine Protease)IBA 01/2021 - 11/2012
2	Heme (Haem)IBA 01/2023 - 01/2020
2	Carrier Proteins (Binding Protein)IBA 01/2016 - 09/2006
2	Cysteine (L-Cysteine)FDA Link 01/2008 - 08/2002
2	LigandsIBA 09/2006 - 03/2005
2	statineIBA 06/2005 - 06/2004
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 03/2004 - 08/2003
1	Adenosine Triphosphatases (ATPase)IBA 01/2023
1	PerforinIBA 01/2023
1	Phosphatidylcholines (Phosphatidylcholine)IBA 12/2022
1	Choline (Choline Chloride)IBA 12/2022
1	glycerophosphodiester phosphodiesteraseIBA 12/2022
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2022
1	Essential Amino AcidsIBA 01/2021
1	Boronic AcidsIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 12/2020
1	LipocalinsIBA 01/2020
1	Virulence Factors (Pathogenicity Factors)IBA 01/2020
1	NexusIBA 01/2020
1	hemozoinIBA 01/2020
1	Serine (L-Serine)FDA Link 01/2020
1	Cyclic AMP (AMP, Cyclic)IBA 01/2019
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2019
1	Cyclic NucleotidesIBA 01/2019
1	Explosive Agents (Explosives)IBA 01/2018
1	LipidsIBA 11/2016
1	Phospholipid Transfer ProteinsIBA 11/2016
1	SaponinsIBA 08/2013
1	Cre recombinaseIBA 05/2013
1	Recombinases (Recombinase)IBA 05/2013
1	Peptides (Polypeptides)IBA 03/2012
1	Adenosine Triphosphate (ATP)IBA 03/2012
1	Malaria VaccinesIBA 12/2011
1	Surface Antigens (Surface Antigen)IBA 03/2010
1	FurinIBA 04/2009
1	Glycoproteins (Glycoprotein)IBA 04/2009
1	Aspartic Acid ProteasesIBA 06/2004
1	plasmepsin IIIBA 01/2004
1	Suramin (Suramin Sodium)IBA 11/2003
1	Subtilisins (Subtilopeptidase A)IBA 08/2002
1	DisulfidesIBA 08/2002

Therapy/Procedure

1	Therapeutics 12/2009